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目的:探讨Wnt5a在甲状腺乳头状癌(PTC)组织中的表达及意义。方法:收集术后病理确诊为PTC的患者石蜡标本47例,包括癌组织及癌旁组织,以及手术切除的PTC新鲜标本及其癌旁组织10例。分别采用免疫组化法及real-time PCR检测Wnt5a在PTC及癌旁组织中的表达。结果:47例患者的石蜡标本中,PTC及癌旁组织中,Wnt5a在PTC组织的阳性表达率为68.09%(32/47),在癌旁甲状腺组织为6.38%(3/47),两者间差异有统计学意义(P<0.01);统计分析显示,Wnt5a的表达与患者的性别及年龄无关(均P>0.05),而与肿瘤的TNM分期、淋巴结转移有关(P<0.05或P<0.01)。10例手术标本检测显示,PTC中Wnt5a mRNA的表达明显高于其的癌旁甲状腺组织(6.43±1.38 vs.1.12±0.59,P<0.01)。结论:PTC组织中Wnt5a表达水平增高,这可能对PTC的发生和发展有着重要的作用。
Objective: To investigate the expression and significance of Wnt5a in papillary thyroid carcinoma (PTC). Methods: Totally 47 cases of paraffin specimens were collected from patients with pathologically diagnosed PTC. The specimens included cancer tissues and adjacent tissues, as well as freshly resected PTC specimens and their adjacent tissues. Immunohistochemistry and real-time PCR were used to detect the expression of Wnt5a in PTC and adjacent tissues respectively. Results: The positive rate of Wnt5a in PTC tissues and para-cancerous tissues was 68.09% (32/47) in paraffin-embedded specimens of 47 patients and 6.38% (3/47) in para-cancerous tissues, both The statistical analysis showed that the expression of Wnt5a was not related to the gender and age of patients (all P> 0.05), but correlated with TNM stage and lymph node metastasis (P <0.05 or P < 0.01). Ten cases of surgical specimens showed that the expression of Wnt5a mRNA in PTC was significantly higher than that in parathyroid tissue (6.43 ± 1.38 vs.1.12 ± 0.59, P <0.01). Conclusion: The increased expression of Wnt5a in PTC tissue may play an important role in the occurrence and development of PTC.