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众多因素可引起糖尿病肾病 (DN)的发生 ,多元醇通路的激活可造成渗透损伤、细胞信号传递的损伤 ,并与肾脏细胞外基质 (ECM )的沉积有关 ,循环蛋白的非酶糖化和DN早期的血流动力学异常与ECM的沉积相关。近年的研究表明 ,DN发病有遗传因素的影响。在众多的致病因素中各种细胞因子可能起着中介作用 ,尤以转化生长因子 (TGF β1)为甚。
A number of factors contribute to the development of diabetic nephropathy (DN). Activation of the polyol pathway can result in osmotic damage, impairment of cell signaling, and deposition of the extracellular matrix (ECM) of the kidney, nonenzymatic glycation of circulating proteins and early DN Hemodynamic abnormalities correlate with ECM deposition. Recent studies have shown that the incidence of DN genetic factors. A variety of cytokines in a variety of cytokines may play an intermediary role, especially with transforming growth factor (TGFβ1) is even more.