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目的研究血清心肌肌钙蛋白-I(cTn-I)水平测定对新生儿窒息心肌损伤的早期诊断价值。方法对80例轻、重度窒息新生儿及40例正常新生儿于生后18～24h经股静脉抽血4ml送检,检测cTn-I、肌酸肌酶(CK-MB)水平,采用非参数秩和检验多样本间的两两比较。结果各组窒息新生儿血清cTn-I水平明显增高,并与窒息程度呈正比,经统计学处理,对照组与轻度组、重度组比较均有统计学意义(P<0.01),轻度组与重度组比较有统计学意义(P<0.01)。结论 cTn-I浓度与新生儿窒息程度密切相关,窒息越重,cTn-I值越高,心肌损害越严重。应常规检测窒息新生儿的cTn-I,以及时治疗,改善预后。
Objective To investigate the value of serum cardiac troponin-I (cTn-I) in the early diagnosis of neonatal asphyxia myocardial injury. Methods Totally 80 neonates with mild and severe asphyxia and 40 normal newborns were enrolled in 4ml blood samples collected from the femoral vein 18 ~ 24h after birth. The levels of cTn-I and creatine kinase (CK-MB) And test multiple comparisons between samples. Results Serum levels of cTn-I in neonates with asphyxia were significantly higher than those in control group (P <0.01), and those in mild group Compared with the severe group was statistically significant (P <0.01). Conclusions The concentration of cTn-I is closely related to the degree of neonatal asphyxia. The heavier asphyxia, the higher the cTn-I value, the more severe myocardial damage. Asphyxia neonatal cTn-I should be routinely tested, and timely treatment to improve the prognosis.