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研究目的探讨β_2—微球蛋白与妊娠高血压综合征临床意义研究设计病例对照研究研究对象 36例妊娠高血压综合征患者,孕周28～40周,年龄22～30岁;对照组为40例正常晚期妊娠孕妇。处理方法妊娠高血压综合征患者及正常孕妇血清和尿,用放射免疫分析法测定β_2—微球蛋白水平。同时测血尿素氮(BUN)以对照,测定结果进行t检验。测定结果 36例妊娠高血压综合征患者及40例正常晚期妊娠孕妇血清β_2—微球蛋白测定值分别为4.98±1.50mg/L和2.57±1.43mg/L(p<0.01,t检验)。29例妊娠高血压综合征患者及23例正常孕妇尿β_2—微球蛋白水平分别为1.03±0.91mg/L和0.55±0.40mg/L(P<0.05)。33例妊娠高血压综合征患者及25例正常孕妇,血尿素氮(BUN)测定值分别为6.16±4.17mmol/L和6.173±3.84mmol/L(P>0.05)。结论妊娠高血压综合征患者血清及尿β_2—微球蛋白水平均明显高于正常晚期妊娠孕妇,血清及尿β_2—微球蛋白测定是监测妊娠高血压综合征患者肾功能受损较敏感的方法。
Objective To investigate the clinical significance of β_2-microglobulin and pregnancy-induced hypertension syndrome (Hypertension syndrome). A case-control study was conducted in 36 cases of pregnancy-induced hypertension (Hypertension syndrome) gestational age ranging from 28 to 40 weeks, ranging in age from 22 to 30 years and in the control group, 40 cases Normal late pregnancy pregnant women. Methods Serum and urine of patients with pregnancy induced hypertension and normal pregnant women were measured by radioimmunoassay to determine the level of β_2-microglobulin. At the same time measure blood urea nitrogen (BUN) as a control, the results of t test. Determination of Results 36 cases of pregnancy induced hypertension syndrome and 40 cases of normal late pregnancy serum β 2-microglobulin measured values were 4.98 ± 1.50mg / L and 2.57 ± 1.43mg / L (p <0.01, t test). The levels of urinary β_2-microglobulin in 29 patients with pregnancy-induced hypertension and 23 normal pregnant women were 1.03 ± 0.91mg / L and 0.55 ± 0.40mg / L, respectively (P <0.05). The blood urea nitrogen (BUN) values were 6.16 ± 4.17mmol / L and 6.173 ± 3.84mmol / L in 33 patients with pregnancy induced hypertension and 25 normal pregnant women, respectively (P> 0.05). Conclusion Serum and urinary β_2-microglobulin levels in patients with pregnancy-induced hypertension are significantly higher than those in normal late pregnant women. Serum and urinary β_2-microglobulin levels are more sensitive in monitoring renal dysfunction in patients with pregnancy-induced hypertension .