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目的 探索母牛分支杆菌疫苗在治疗癌性胸液中的作用。方法 肺癌并癌性胸液 4 0例 ,配对随机分组 ,治疗组胸腔内灌注母牛分支杆菌疫苗 10 0 0 μg 2～ 3次 ,对照组胸腔内灌注顺铂 4 0～6 0mg 2～ 3次 ,两组均同时给以全身化疗。结果 治疗组完全有效率 6 0 % (12 / 2 0 )明显高于对照组2 0 % (4/ 2 0 ) ,治疗组的有效率 90 % (18/ 2 0 )亦高于对照组的 55% (11/ 2 0 ) ,P <0 .0 5。结论 母牛分支杆菌疫苗可用于癌性胸液的局部治疗。
Objective To explore the role of the vaccine against Mycobacterium vaccae in the treatment of cancerous pleural fluid. Methods Forty patients with lung cancer and cancerous pleural effusion were randomly divided into two groups. The treatment group was intravitreally infused with 100 μg of M. vaccae vaccine 2 to 3 times, and the control group was infused with cisplatin 40 to 60 mg 2 to 3 times. Both groups were given systemic chemotherapy at the same time. Results The total effective rate in the treatment group was 60% (12/20), which was significantly higher than that in the control group (20%) (4/20). The effective rate in the treatment group was also 90% (18/20) higher than that in the control group (55/55). % (11/20), P <0. Conclusion M. vaccae vaccine can be used for topical treatment of cancerous pleural fluid.