论文部分内容阅读
目的探讨不同血尿蛋白指标在老年高血压病患者不同分期与不同危险分层中的意义。方法随机挑选老年高血压病患者 84例 ,进行分级及危险分层后 ,分别测定其血尿素氮 (BUN)、血肌酐 (Cr)、尿白蛋白 (Alb)、血尿 β2 微球蛋白 (β2 MG)、血尿球蛋白G(IgG)的浓度。分析预测肾功能损害的敏感指标。结果在低危级 1级高血压患者中 ,尿 β2 MG检测的阳性率均为最高 (P <0 .0 5)。随着血压级别的增加和危险分层的增高 ,尿Alb ,血尿 β2 MG和IgG的值比低一级或低一层患者均显著增高 (P <0 .0 5或P <0 .0 1 )。在 3级高血压和极高危患者中 ,才有BUN、Cr的变化。结论血尿 β2 MG、IgG及尿Alb是反映老年高血压病患者肾功能损害的较早期指标。β2 MG是其中最敏感的指标 ,尿Alb和尿 β2 MG对于老年高血压患者预后的判定有一定的临床意义
Objective To explore the significance of different urinary proteinuria indexes in different stages and different risk stratification in elderly patients with hypertension. Methods Eighty-four elderly patients with essential hypertension were randomly selected. After grading and risk stratification, the levels of blood urea nitrogen (BUN), serum creatinine (Cr), urinary albumin (Alb), β2-microglobulin ), Blood and urine globulin G (IgG) concentrations. Analysis of predictive indicators of renal damage. Results The positive rate of urinary β2 MG was the highest in low-risk grade 1 hypertensive patients (P <0.05). With the increase of blood pressure level and the increase of risk stratification, urinary Alb, hematuria, β2 MG and IgG were significantly higher than those in the lower or lower level (P <0.05 or P <0.01) . In grade 3 hypertension and very high-risk patients, only BUN, Cr changes. Conclusion Hematuria β2 MG, IgG and urinary Alb are the early indicators of renal dysfunction in elderly patients with hypertension. β2 MG is one of the most sensitive indicators of urinary Alb and urinary β2 MG for the determination of the prognosis of elderly patients with hypertension has some clinical significance