成骨不全常被认为是儿童最常见的可遗传性骨机能障碍。但是,大部分成骨不全病人,可与正常人一样幸存。这种疾病的显著特点之一是青春期骨折率明显的下降,其原因尚不清楚。青春期时激素变化可能是一个重要因素。如果这种说法能够成立,那么,患成骨不全的妇女绝经可能给患者带来额外负担。作者研究了成骨不全的45例女性和20例男性的骨折率及其年龄变化的因素。调查了成骨不全患者的情况,其中有:既往 Osteogenesis imperfecta is often considered the most common inheritable bone dysfunction in children. However, most patients with osteogenesis imperfecta survive as well as normal people. One of the salient features of this disease is the marked decline in the rate of adolescent fracture, the reason for which is not clear. Changes in puberty may be an important factor. If this statement holds true, then, women with osteogenesis imperfecta may have an extra burden on the patient. The authors studied the factors that affect the rate of fracture and age in 45 women with osteogenesis imperfecta and 20 men. Investigated the situation of patients with osteogenesis imperfections, among them: past