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为探讨自由基在过期四环素致肝脏损伤中的毒理作用，本研究通过检测肝脏谷胱甘肽过氧化物酶（ＧＳＨ—Ｐｘ）的活性和过氧化脂质（ＬＰＯ）的含量，来进一步阐明过期四环素致肝脏损伤的作用机理。结果表明：（１）用药组小鼠肝脏的ＧＳＨ—Ｐｘ活性较空白对照组显著降低；（２）用药组小鼠肝脏内ＬＰＯ含量较空白对照组显著升高；（３）用药组小鼠肝脏内ＧＳＨ—Ｐｘ／ＬＰＯ比值较对照组明显降低；（４）用药组ＧＳＨ—Ｐｘ活性的降低和ＬＰＯ含量的升高与累积摄药量呈正比关系。提示：自由基在过期四环素致肝脏损伤中具有重要作用。
In order to explore the toxicological effects of free radicals on tetracycline-induced liver injury, we further clarified the activity of glutathione peroxidase (GSH-Px) and the content of lipid peroxide (LPO) Expired tetracycline-induced liver injury mechanism of action. The results showed that: (1) The activity of GSH-Px in the liver of the treated group was significantly lower than that of the blank control group; (2) The LPO content in the liver of the treated group was significantly higher than that of the blank control group; (3) The ratio of GSH-Px / LPO was significantly lower than that of the control group; (4) The decrease of GSH-Px activity and the increase of LPO content were directly proportional to the cumulative dose. Tip: Free radicals in tetracycline-induced liver damage has an important role.