论文部分内容阅读
癌肿病人的肾上腺功能衰竭(AI)常不易认别,因其恶心呕吐、食欲减退和直位性低血压等表现并无特异性,易误为晚期癌肿或治疗副作用所致。AI有原发和继发之分,前者指肾上腺皮质三个功能带均受损害,而后者仅有糖皮质激素不足,伴随束状带萎缩。在癌肿病人,原发性AI的病因有:淋巴瘤浸润双侧肾上腺,伴随抗凝状态或脓毒症的出血性坏死。服用氨基苯乙哌啶酮、Ketoconazole、邻对二氯苯二氯乙烷或苏拉明等药物的病人可发生肾上腺类固醇生成损害。癌肿转移必须破坏90%以上的肾上腺组织才会发生AI。在5%癌肿病人发生垂体或下视丘转移,
Adrenal failure (AI) in patients with cancer is often not easy to identify because of nausea and vomiting, loss of appetite, and hypotension, which are not specific, and are easily mistaken for advanced cancer or treatment of side effects. AI has both primary and secondary points. The former refers to the impairment of the three functional zones of the adrenal cortex, whereas the latter has only glucocorticoid deficiency, with atrophic bundles. In cancer patients, the primary cause of AI is lymphoma infiltrating the bilateral adrenal glands, with hemorrhagic necrosis of anticoagulation or sepsis. Adrenocorticosteroid damage can occur in patients taking drugs such as aminozidhione, Ketoconazole, o-dichlorodichloroethane, or suramin. Metastasis of cancer must destroy more than 90% of adrenal glands to produce AI. Pituitary or hypothalamic metastasis occurred in 5% of cancer patients.