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目的研究紫心甘薯总黄酮(PSPF)的降糖及其抗氧化作用。方法采用链脲佐菌素(STZ,65 mg.kg-1)腹腔注射诱导形成糖尿病大鼠模型,实验组大鼠分为正常对照组、糖尿病模型组、PSPF高剂量组(240 mg.kg-1),中剂量组(120 mg.kg-1),低剂量组(60 mg.kg-1),阳性对照组(二甲双胍,90 mg.kg-1),PSPF灌胃4周,每天测量体重、饮食和饮水量,初期、中期、后期测量空腹血糖(FBG),最后取血测定糖化血清蛋白(GSP)、丙二醛(MDA)、还原型谷胱甘肽(GSH)、超氧化物歧化酶(T-SOD)的变化并测量餐后2 h血糖(2 h BG)。结果 PSPF灌胃4周后,糖尿病大鼠“三多一少”症状明显改善,与模型组相比,高、中灌胃组均有效降低FBG、GSP、2 h BG、MDA,提高大鼠血清中的T-SOD、GSH含量(P<0.01);低剂量灌胃组均可明显改善FBG、GSP(P<0.05)、MDA、T-SOD含量(P<0.01);血糖与抗氧化指标统计学分析相关性显著(P<0.05)。结论 PSPF可以明显改善糖尿病大鼠的血糖异常,提高大鼠抗氧化能力。
Objective To study the hypoglycemic effect and anti-oxidative effect of total flavonoids from sweet potato (PSPF). Methods Diabetic rats were induced by intraperitoneal injection of streptozotocin (STZ, 65 mg.kg-1). The rats in experimental group were divided into normal control group, diabetic model group and PSPF high-dose group (240 mg.kg- 1), the middle dose group (120 mg.kg-1), the low dose group (60 mg.kg-1), the positive control group (metformin, 90 mg.kg-1) Fasting blood glucose (FBG) was measured in the early, middle and late stages of blood glucose, serum creatinine (GSP), malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase Changes in enzyme (T-SOD) and measurement of 2 h postprandial blood glucose (2 h BG). Results After four weeks of PSPF treatment, the symptoms of diabetic rats were significantly improved. Compared with the model group, the high-dose and middle-dose groups effectively reduced FBG, GSP, BG and MDA at 2 h (P <0.01). The levels of FBG and GSP (P <0.05), MDA and T-SOD in serum were significantly improved (P <0.01) Statistical analysis showed significant correlation (P <0.05). Conclusion PSPF can significantly improve the abnormal blood glucose in diabetic rats and increase the anti-oxidative capacity in rats.