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目的 探讨低分子肝素 (LMWHs)对急性脑梗死的疗效。方法 选用 88例急性脑梗死病人 ,其中 40例用常规治疗为对照组 ;余 48例除常规治疗外 ,加用LMWHs 0 .4ml皮下注射bid× 10d为治疗组。两组在治疗前后均行神经功能缺损评分 (NDS)和临床疗效评定。结果 治疗组于治疗后NDS较治疗前明显下降 (P <0 .0 1) ,治疗组显效率 6 6 .7% ,两组比较差异有显著意义 (P <0 .0 5 )。结论 急性脑梗死病人早期给予LMWHs有助于神经功能的恢复 ,且无增加再出血的危险。
Objective To investigate the effect of low molecular weight heparin (LMWHs) on acute cerebral infarction. Methods Eighty-eight patients with acute cerebral infarction were selected, of whom 40 were treated with conventional therapy as control group. The remaining 48 patients were treated with LMWHs 0.4 ml subcutaneously twice a day for 10 days. Before and after treatment in both groups, neurological deficit score (NDS) and clinical efficacy evaluation. Results After treatment, the NDS in treatment group was significantly lower than that before treatment (P <0.01), and the effective rate in treatment group was 66.7%. There was significant difference between the two groups (P <0.05). Conclusion Early administration of LMWHs in patients with acute cerebral infarction contributes to the recovery of neurological function without the risk of increased rebleeding.