盐酸西布曲明 (Ｓｉｂｕｔｒａｍｉｎｅ)在临床上用于治疗肥胖症 ,多数耐受性良好 ,但可使血压正常者的收缩压和舒张压升高 0 .13～ 0 .4ｋＰａ。对象与方法　采用随机、双盲、安慰剂对照、多中心研究 ,包括筛选阶段、2～ 10周的安慰剂治疗阶段及 52周的西布曲明治疗阶段。仅在 Sibutramine hydrochloride is clinically used to treat obesity and is mostly tolerated, but systolic and diastolic blood pressure can be increased by .13 to .4 kPa in normotensive subjects. Subjects and Methods Randomized, double-blind, placebo-controlled, multicenter studies included a screening phase, a 2 to 10 week placebo treatment phase and a 52 week sibutramine treatment phase. only at