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目的探讨2型糖尿病患者血液流变学指标变化及检测意义。方法选择2011年3月—2012年5月就诊的2型糖尿病患者114例作为糖尿病组,选择30例同期进行健康体检的年龄、性别匹配者作为对照组。待检者采血前1 d禁食高脂饮食,妇女应尽量避开月经期。于清晨空腹采肘静脉血5 ml存放于肝素抗凝试管,2 h内送检。采用北京众驰伟业ZS-9200型全自动血流变分析仪测定全血粘度、血浆粘度、纤维蛋白原等血液流变学指标,红细胞压积采用温氏法测定。HbA1c检测采用微柱法。计量资料采用t检验,P<0.05为差异有统计学意义。结果糖尿病组全血高切、中切、低切粘度、血浆粘度、纤维蛋白原、红细胞沉降率[(5.01±0.52)、(5.13±0.73)、(5.13±0.73)、(1.64±0.23)mPa·s、(19.48±8.28)mm/h]均明显高于对照组(均P<0.05)。而红细胞压积差异无统计学意义(P>0.05)。全血高切、中切、低切粘度、血浆粘度随HbA1c水平升高而增加,比较差异均有统计学意义(均P<0.05),而红细胞沉降率和红细胞压积比较差异均无统计学意义(均P>0.05)。结论 2型糖尿病患者存在血液流变学的异常改变,且与血糖水平密切相关。
Objective To investigate the changes of blood rheology indexes in type 2 diabetic patients and its significance. Methods 114 patients with type 2 diabetes mellitus who were treated from March 2011 to May 2012 were selected as the diabetes mellitus group. Thirty healthy age and sex matched subjects were selected as the control group. Awaiting seizure 1 d before fasting high-fat diet, women should try to avoid the menstrual period. Fasting in the early morning elbow venous blood 5 ml stored in heparin anticoagulant tubes, within 2 h for submission. Using Beijing Zhong Chi Albert CHS ZS-9200 automatic blood rheology analyzer for determination of whole blood viscosity, plasma viscosity, fibrinogen and other indicators of hemorheology, hematocrit measured by the method of Winchester. HbA1c detection using micro-column method. Measurement data using t test, P <0.05 for the difference was statistically significant. Results The rates of erythrocyte sedimentation rate (5.01 ± 0.52), (5.13 ± 0.73), (5.13 ± 0.73), (1.64 ± 0.23) mPa · S, (19.48 ± 8.28) mm / h] were significantly higher than those in the control group (all P <0.05). The difference of hematocrit was not statistically significant (P> 0.05). Whole blood high-cut, middle cut, low cut viscosity and plasma viscosity increased with the increase of HbA1c, with statistical significance (all P <0.05), but there was no significant difference in erythrocyte sedimentation rate and hematocrit Significance (all P> 0.05). Conclusion There is an abnormal change of hemorheology in type 2 diabetic patients, which is closely related to blood glucose level.