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目的探讨电化学发光免疫分析法检测HBsAg和HBeAg的COI值在疗效监测中的意义。方法分析139例患者HBsAg和HBeAg、HBeAg和HBV DNA、HBsAg和HBV DNA在疗程中的规律和相关性,并通过5例标本观察HD-HOOK效应对检测HBsAg和HBeAg的影响。结果①HBsAg和HBeAg的COI值呈负相关(相关系数为-0.26,P<0.01),两者的变化规律60.0%(45/75)为HBsAg COI值随着HBeAg COI值下降而上升;②HBeAg COI值与HBV DNA含量呈正相关(相关系数为0.33,P<0.01),两者的变化规律63.3%(62/98)为HBeAg COI值与HBV DNA含量变化一致;③HBsAg COI值与HBV DNA含量呈负相关(相关系数为-0.34,P<0.01),两者的变化规律52.4%(54/103)为HBsAg的COI值随着HBV DNA的含量的下降(包括HBV DNA阴性)而上升;④HD-HOOK效应对HBsAg检测有影响,对HBeAg检测没有影响。结论在反映血清中病毒被抑制的治疗效果时HBsAg COI值意义不大,HBeAg COI值较有价值。
Objective To investigate the significance of detecting the COI of HBsAg and HBeAg by electrochemiluminescence immunoassay in the curative effect monitoring. Methods The regularity and correlation of HBsAg, HBeAg, HBeAg and HBV DNA, HBsAg and HBV DNA in 139 patients were analyzed. The effects of HD-HOOK on HBsAg and HBeAg were observed by five specimens. Results ① The COI values of HBsAg and HBeAg were negatively correlated (the correlation coefficient was -0.26, P <0.01). The change law of both of them was 60.0% (45/75), the value of HBsAg COI increased with the decrease of HBeAg COI value; ② The value of HBeAg COI And the content of HBV DNA were positively correlated (the correlation coefficient was 0.33, P <0.01), the change rule of both was 63.3% (62/98), the change of HBeAg COI value was consistent with the change of HBV DNA content; ③HBsAg COI value was negatively correlated with HBV DNA content (Correlation coefficient -0.34, P <0.01). The change of both of them showed that the COI value of 52.4% (54/103) HBsAg increased with the decrease of HBV DNA content (including HBV DNA negative) Has an effect on HBsAg testing and has no effect on HBeAg testing. Conclusions The HBsAg COI value is not significant in reflecting the therapeutic effect of the virus in the serum and the value of HBeAg COI is more valuable.