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目的研究参熊心痛丸对心脏血流动力学的影响。方法犬十二指肠给予不同剂量参熊心痛丸后,测定心脏血流动力学参数。结果给予参熊心痛丸2g/kg后,冠脉流量明显增加,冠脉阻力降低,心率减慢,降低左室舒张末期压;对左室收缩性能、左室做功及心脏泵血功能无明显影响。结论参熊心痛丸缓解心绞痛的作用是通过扩张冠脉,增加冠脉血流量,从而增加氧的供应,而主要不是通过减少氧的消耗来实现的。
Objective To study the effect of Shenxiong Xintong Pill on cardiac hemodynamics. Methods Dogs were given different doses of Shen Xiong Xin Tong Wan in the duodenum, and cardiac hemodynamic parameters were measured. Results After given Shenxiong Xintong pill 2g/kg, the coronary blood flow increased significantly, the coronary resistance decreased, the heart rate slowed, and the left ventricular end-diastolic pressure was decreased. There was no significant effect on the left ventricular systolic performance, left ventricular work and cardiac pump function. . Conclusion The effect of Shenxiong Xintong pill in relieving angina pectoris is to increase the oxygen supply by expanding the coronary artery and increasing the coronary blood flow, which is mainly achieved by reducing the consumption of oxygen.