血栓性血小板减少性紫癜(TTP)是以发热,血小板减少,微血管病性溶血性贫血,肾功能不全及各种神经系统异常为特点的综合症。根据牙龈活检可见透明的微血栓堵塞终末小动脉及毛细血管而诊断。但其假阴性率高,故常在尸检时才作出病理性诊断。多年来,曾用抗菌素类、类固醇激素、免疫抑制剂。抗凝剂及脾切除术等几种方法联合治疗偶然取得成功。1959年Rubinstein等应用新鲜全血作交换输血,治疗1例TTP得到迅速且长期的恢复。他们认为这种效力可能是由于交换清除了“抗体”之故。此后Piscotta等复习了25例用这种方法治疗 Thrombotic thrombocytopenic purpura (TTP) is a syndrome characterized by fever, thrombocytopenia, microangiopathic hemolytic anemia, renal insufficiency, and various neurological disorders. According to the gingival biopsy can be seen transparent microthrombus plug the terminal arterioles and capillaries and diagnosis. However, its false-negative rate is high, so often in the autopsy to make pathological diagnosis. Over the years, have used antibiotics, steroid hormones, immunosuppressive agents. Anticoagulants and splenectomy, and several other methods combined treatment of accidental success. In 1959, Rubinstein et al. Applied fresh whole blood for transfusion and treated 1 patient with TTP for prompt and long-term recovery. They think this effect may be due to the clearing of the “antibody”. Since then Piscotta reviewed 25 cases treated with this method