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目的 研究扬子毛茛的化学成分。方法 应用多种色谱方法和色谱材料进行提取、分离和纯化 ,用各种现代光谱方法并结合文献对分得的化合物进行结构解析。结果 从扬子毛茛的 95 %乙醇提取物中分到十三个化合物 ,其中五个为黄酮苷类化合物 ,分别命名为芹菜素 4′ O α L 鼠李糖苷 (1) ,芹菜素 7 O β D 葡萄糖苷 4′ O α L 鼠李糖苷 (2 ) ,芹菜素 8 C α L 阿拉伯糖苷 (3) ,芹菜素 8 C β D 半乳糖苷 (4 ) ,小麦黄素 7 O β D 葡萄糖苷 (5 ) ;其余八个分别为小麦黄素 (6 ) ,木犀草素 (7) ,东莨菪内酯 (8) ,秦皮乙素 (9) ,滨蒿内酯 (10 ) ,阿魏酸 (11) ,原儿茶酸 (12 )和小毛茛内酯 (13)。此外还对这些化合物的体外抗癌活性进行了初步的测试。结论 化合物 1- 12为首次从该属植物中分到 ,化合物 13为首次从该种植物中分到 ,其中化合物 1为新的天然产物 ,化合物 2和 3首次报道了其碳谱数据。生物活性测试结果表明化合物 1对BEL 74 0 7及A5 4 9细胞的IC50 值分别为 4 3及 77μg·mL- 1 ,化合物 8和 10对KB细胞的IC50 分别为 78和 4 4 μg·mL- 1 ,对HL 6 0细胞的IC50 均为 85 μg·mL- 1 。化合物7对所测试的四种肿瘤细胞株均显示一定的细胞毒活性 ,其对KB ,BEL 74 0 7,A5 4 9及HL 6 0细胞的IC50 分别为
Objective To study the chemical constituents of F. sinensis. Methods A variety of chromatographic methods and chromatographic materials were used for extraction, separation and purification. Structural analysis of the separated compounds was performed using various modern spectroscopic methods combined with literature. Results Thirteen compounds were extracted from the 95% ethanol extracts of F. serrata. Five of them were flavone glycosides. They were named apigenin 4’ O α L rhamnoside (1), apigenin 7 O β D. Glucoside 4’ O α L rhamnoside (2), apigenin 8 C α L arabinoside (3), apigenin 8 C β D galactoside (4), and lutein 7 O β D glucoside (5 The remaining eight are respectively lutein (6), luteolin (7), scopoletin (8), aesculin (9), scoparone lactone (10), ferulic acid (11) Protocatechuic acid (12) and ranunculus lactone (13). In addition, preliminary tests were performed on the anticancer activity of these compounds in vitro. Conclusion Compound 1- 12 was isolated from this genus for the first time. Compound 13 was isolated from the plant for the first time. Compound 1 was a new natural product. Compounds 2 and 3 reported their carbon spectrum data for the first time. The biological activity test results showed that the IC50 values of compound 1 against BEL 74 0 7 and A549 cells were 4 3 and 77 μg·mL - 1 , and the IC 50 values of compound 8 and 10 against KB cells were 78 and 4 4 μg·mL- 1 The IC50 of HL 60 cells was 85 μg·mL - 1 . Compound 7 showed a certain cytotoxic activity against the four tumor cell lines tested. The IC50 values for KB, BEL 74 0 7, A549, and HL 60 cells were