细胞免疫是肾小球疾病发生发展的机制之一,研究表明肾小管上皮细胞(TEC)可作为抗原呈递细胞(APC)参与细胞免疫。B7家族作为抗原提呈过程中的最重要的协同刺激分子,其成员近年陆续发现,它们可使TEC发挥对T细胞的免疫调节作用。本文就B7家族成员及其在TEC免疫调节中的作用做初步探讨。 Cellular immunity is one of the mechanisms for the development of glomerular diseases. Studies have shown that the tubular epithelial cells (TECs) are involved in cellular immunity as antigen presenting cells (APC). As the most important costimulatory molecule in the process of antigen presentation, the B7 family members have discovered in recent years that they can make TEC play an immunomodulatory role on T cells. In this paper, the B7 family members and their role in TEC immune regulation to do a preliminary discussion.