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[目的]探讨空气污染与人群恶性肿瘤住院人数的关联性。[方法]收集甘肃省金昌市2007—2010年大气污染(PM10、SO2和NO2)及气象观测数据,以及同期金昌队列人群全部恶性肿瘤住院病例。采用半参数广义相加模型在调整混杂因素后分析大气污染物浓度与该队列人群恶性肿瘤住院人数的关联性。[结果]共收集金昌队列人群恶性肿瘤住院病例2 707例。当天(L0)的SO2及平均累积滞后4天(L04)的NO2与恶性肿瘤住院人数的RR值最大,分别为1.043(1.002~1.085)及1.163(1.091~1.239),PM10及NO2对男性及60岁以上人群的恶性肿瘤住院人数的RR值较女性和60岁及以下人群大。多因素污染物模型中,SO2及NO2对PM10的影响具有协同效应,NO2表现出显著且独立的健康效应。[结论]空气污染与金昌队列人群恶性肿瘤患病住院人数之间具有一定的关联性。
[Objective] To investigate the correlation between air pollution and hospitalization of malignant tumors in population. [Method] The data of atmospheric pollution (PM10, SO2 and NO2) and meteorological observation from 2007 to 2010 in Jinchang City, Gansu Province were collected, and all the inpatient cases of malignant tumors in Jinchang cohort during the same period were collected. The semiparametric generalized additive model was used to analyze the association between air pollutant concentrations and the number of hospitalized malignant tumors in this cohort after adjusting confounding factors. [Results] A total of 2 707 hospitalized cases of malignant tumors in Jinchang cohort were collected. The odds ratio of NO2 and malignant inpatients with SO2 and L4 (L04) were 1.043 (1.002-1.885) and 1.163 (1.091-1.239) respectively, and PM10 and NO2 were the highest in male and 60 The RR for hospital admission for malignant tumors over the age group is larger than for women and people aged 60 and under. In the multi-factor pollutant model, SO2 and NO2 have a synergistic effect on PM10, and NO2 shows significant and independent health effects. [Conclusion] There is a certain relationship between air pollution and the prevalence of malignant tumors in Jinchang cohort.