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目的:观察补肾通络方对骨质疏松大鼠骨代谢和骨密度的干预效应,并探讨其作用机制。方法:通过卵巢去势的方法造成大鼠骨质疏松模型,造模后随机分为6组:假手术组、模型组、仙灵骨葆组、补肾基础组、通络组、补肾通络组。治疗10周后,检测大鼠体重、血清钙(S-Ca)、血清磷(S-P),血清碱性磷酸酶(S-ALP)及骨密度。结果:与假手术组比较,骨质疏松大鼠体重增加,S-Ca降低,S-P上升,S-ALP上升,骨密度下降,各组均有显著性差异(P<0.05)。与模型组相比,各治疗组骨质疏松大鼠体重增长受到抑制,但差异不显著;S-Ca上升,S-P下降,其中补肾通络组有显著差异(P<0.05);S-ALP下降,各组均有显著性差异(P<0.01);骨密度均上升,补肾通络组骨密度值高于补肾基础组或通络组,其中补肾基础组有显著差异(P<0.05),而通络组及补肾通络组有显著差异(P<0.01)。结论:补肾通络中药可以有效降低骨质疏松大鼠的骨代谢异常旺盛水平,明显提高其骨密度,补肾中药与通络中药在治疗骨质疏松方面具有良好的协同增效作用。
Objective: To observe the effect of Bushen Tongluo Recipe on bone metabolism and bone mineral density in rats with osteoporosis and its mechanism. Methods: Osteoporosis model was induced by ovariectomized rats. After modeling, rats were randomly divided into 6 groups: sham operation group, model group, xianlinggubao group, basic kidney invigoration group, Tongluo group, Bushen Tongluo group . After 10 weeks of treatment, body weight, S-Ca, S-P, S-ALP and BMD of the rats were measured. Results: Compared with sham operation group, body weight, S-Ca, S-P increased, S-ALP increased and bone mineral density decreased in osteoporotic rats. There was significant difference between the two groups (P <0.05). Compared with the model group, the weight gain of osteoporosis rats in each treatment group was inhibited, but the difference was not significant; S-Ca increased, SP decreased, and there was significant difference in Bushen Tongluo group (P <0.05); S-ALP decreased (P <0.01). The BMD of Bushen Tongluo group was higher than that of Bushen Tongluo group or Tongluo group (P <0.05), but there was a significant difference Tongluo group and Bushen Tongluo group were significantly different (P <0.01). Conclusion: Bushen Tongluo Chinese medicine can effectively reduce the abnormally high bone metabolism in osteoporosis rats and significantly increase its bone density. Bushen Chinese traditional medicine and Tongluo Chinese medicine have good synergistic effects in the treatment of osteoporosis.