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目的探讨长期应用普罗布考联合阿司匹林治疗大脑中动脉狭窄的效果。方法选取经头颅彩色多普勒超声诊断为大脑中动脉狭窄患者86例作为研究对象,采用随机数字表法将患者分为对照组和观察组,对照组给予阿司匹林治疗,观察组在对照组基础上给予普罗布考治疗,均持续用药6个月,治疗前后根据血流峰值(Vp)变化情况评估大脑中动脉狭窄程度,对比治疗前后两组血脂指标的变化。结果观察组治疗后流速正常率和轻度狭窄率分别为11.63%、48.84%,显著高于对照组,重度狭窄率为18.60%,显著低于对照组(46.51%),差异有统计学意义(P<0.05);观察组治疗后三酰甘油、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇分别为(1.25±0.97)、(4.13±1.28)、(1.05±0.57)、(2.71±1.14)mmol/L,均显著低于对照组,差异有统计学意义(P<0.05)。结论长期应用普罗布考联合阿司匹林治疗大脑中动脉狭窄,效果显著。
Objective To investigate the long-term use of probucol plus aspirin in the treatment of middle cerebral artery stenosis. Methods Eighty-six patients with middle cerebral artery stenosis diagnosed by color Doppler ultrasound were selected as study subjects. Patients were divided into control group and observation group by random number table method. The control group was given aspirin. On the basis of the control group Give probucol treatment, continuous medication for 6 months before and after treatment according to changes in blood flow peak (Vp) assessment of stenosis of the middle cerebral artery, comparing the changes of blood lipid indicators before and after treatment. Results After treatment, the normal rate of flow rate and mild stenosis rate in observation group were 11.63% and 48.84%, respectively, which were significantly higher than those in control group (18.60%, significantly lower than 46.51%) (the difference was statistically significant (1.25 ± 0.97), (4.13 ± 1.28), (1.05 ± 0.57), (2.71 ± 0.47), and the total cholesterol, total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol in the observation group after treatment 1.14 mmol / L, all significantly lower than that of the control group, the difference was statistically significant (P <0.05). Conclusion Long-term use of probucol plus aspirin treatment of middle cerebral artery stenosis, the effect is significant.