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目的:围绕止血、凝血等方面,进行复方止血消炎软膏的主要药效学研究。方法:应用小鼠断尾止血和凝血实验,分别观察复方止血消炎软膏对小鼠止血及凝血作用;采用断尾法和玻片法评价复方止血消炎软膏止血凝血作用。结果:复方止血消炎软膏连续肛门给药7d后,能有效缩短小鼠断尾出血时间及凝血时间。结论:复方止血消炎软膏具有一定的止血凝血作用,可作为术后止血收敛的外用药使用。
OBJECTIVE: To study the main pharmacodynamics of compound hemostatic anti-inflammatory ointment in the aspects of hemostasis and coagulation. Methods: The tail hemostatic and coagulation experiments were applied to observe the hemostatic and coagulative effects of compound hemostatic anti-inflammatory ointment on mice respectively. The hemostatic and coagulative effects of compound hemostatic anti-inflammatory ointment were evaluated by tail-cut method and slide method. Results: The compound hemostatic anti-inflammatory ointment after continuous anal administration 7d, can effectively reduce the mouse tail bleeding time and clotting time. Conclusion: The compound hemostatic anti-inflammatory ointment has a certain role in hemostasis and coagulation, which can be used as external medicine for the postoperative hemostasis convergence.