由牙髓炎症继发的根尖周病,主要病因是感染。根管内的细菌及其产物,坏死和分解的组织,甚至牙科修复材料和根管药物可以作为抗原或半抗原而引起根尖周组织的免疫反应,从而导致根尖区的骨质吸收和组织破坏。在病理组织图象中,根尖周病损内存在着淋巴细胞、浆细胞、巨噬细胞以及嗜中性白细胞和肥大细胞,也说明在根尖病变时,局部确实存在着免疫反应。 Periapical disease secondary to pulp inflammation, the main cause is infection. Bacteria and their products in the root canal, necrotic and decomposing tissues, and even dental restoration materials and root canal drugs, can act as antigens or haptens to cause an immune response in the periapical tissue, resulting in bone resorption and tissue in the apical area damage. In the histopathological image, there are lymphocytes, plasma cells, macrophages and neutrophils and mast cells in the periapical lesions. It also shows that there is indeed an immune response locally in the apical lesions.