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目的探讨再生障碍性贫血(简称再障)患者的细胞免疫状态及发病机理。方法应用碱性磷酸酶-抗碱性磷酸酶桥联酶联技术(APAAP)法,检测再障患者的 T 细胞CD3、CD4及 CD8的阳性率,计算 CD4~+/CD8~+比值。结果再障患者 CD3、CD4阳性率显著低于正常对照组(P<0.01和P<0.001)。CD4~+/CD8~+值明显低于对照组(P<
Objective To investigate the cellular immune status and pathogenesis in patients with aplastic anemia (aplastic anemia). Methods The positive rates of CD3, CD4 and CD8 on T cells of patients with aplastic anemia were detected by alkaline phosphatase - alkaline phosphatase (APAAP) method and the ratio of CD4 ~ + / CD8 ~ + was calculated. Results The positive rate of CD3 and CD4 in patients with aplastic anemia was significantly lower than that in the normal controls (P <0.01 and P <0.001). CD4 ~ + / CD8 ~ + value was significantly lower than the control group (P <