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目的：通过检测凋亡细胞探讨双介入并中药治疗中、晚期肝癌的机理。方法：中、晚期肝癌８４例中，男５９例，女２５例，年龄２４～７８岁，随机分成常规肝动脉插管化疗，栓塞并超声引导局部注射鱼肝油酸钠配伍顺铂，口服中药组（治疗组）４６例和单纯肝动脉插管化疗，栓塞组（对照组）３８例，治疗组与对照组在治疗前、后，采用光学显微镜和电子显微镜分别检测凋亡细胞。结果：治疗组治疗前、后的细胞凋亡，即细胞核浓缩、细胞核周围晕轮、浓缩染色质偏位、细胞器萎缩、凋亡小体分别为０∶３２、１∶３８、３∶２８、２∶２２及０∶４２，对照组为０∶３、１∶４、２∶１、１∶２、０∶３。结论：双介入并中药治疗中、晚期肝癌的作用机理除化疗、栓塞所致对肿瘤细胞的直接杀伤作用外，还与鱼肝油酸钠，中药免疫调节作用有关的诱导肿瘤细胞凋亡有关。
OBJECTIVE: To explore the mechanism of dual interventional and traditional Chinese medicine in the treatment of middle and late stage liver cancer by detecting apoptotic cells. Methods: Of the 84 patients with moderate or advanced liver cancer, 59 were males and 25 were females, aged 24-78 years. They were randomly divided into conventional hepatic artery catheterization chemotherapy, embolization and ultrasound-guided local injection of sodium morrhuate and cisplatin, and oral Chinese medicine ( In the treatment group, 46 cases were treated with hepatic arterial catheterization alone and 38 cases in the embolization group (control group). Apoptotic cells were detected by light microscopy and electron microscopy before and after treatment in the treatment group and the control group. RESULTS: Before and after treatment, the apoptosis in the treatment group was 0:32, 1:38, 3:28, 2 respectively. The concentration of nuclei, halo around the nucleus, concentration of condensed chromatin, atrophy of the organelles, and apoptotic bodies were 0:32, 1:38, 3:28, and 2 respectively. At 22 and 0:42, the control group was 0:3, 1:4, 2:1, 1:2, and 0:3. Conclusion: The mechanism of dual interventional and traditional Chinese medicine in the treatment of middle and late stage liver cancer is not only the direct killing effect on tumor cells caused by chemotherapy and embolism, but also related to the induction of apoptosis of tumor cells related to the effects of sodium morrhuate and immunoregulation of traditional Chinese medicine.