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目的:观察不同给药时间分别给予比索洛尔对非杓型原发性高血压患者的降压疗效和血压节律恢复的影响。方法:选取60例非杓型高血压患者,采取随机平行对照试验,观察比索洛尔(n=30)每日早晨(8:00)给药2.5-10mg、比索洛尔(n=30)每日夜间(20:00)给药2.5-10mg治疗8周后的降压疗效。结果:两种给药方法均能降低非杓型高血压患者的全天血压(P<0.05)。两种给药方法在白天的血压控制上无显著性差异(P>0.05),但在夜间血压的控制上夜间服药降压效果具有显著性差异(P<0.05)。夜间服药在血压节律恢复方面优于早晨服药(P<0.05),早晨服药组有10例恢复杓型,夜间服药组有19例恢复杓型。结论:比索洛尔的两种给药方式均能安全有效的降压,但对于非杓型高血压患者夜间服药优于早晨服药,更有利于血压节律的恢复。
OBJECTIVE: To observe the effects of bisoprolol given at different time points on antihypertensive efficacy and blood pressure rhythm recovery in patients with non-dipper essential hypertension. Methods: A total of 60 non-dipper hypertensive patients were selected and randomized controlled trials were conducted. Bisoprolol (n = 30) was given daily for 2.5-10 mg, bisoprolol (n = 30) Day and night (20:00) administered 2.5-10mg 8 weeks after treatment of antihypertensive effect. RESULTS: Both methods of administration reduced blood pressure throughout the day in non-dipper hypertensive patients (P <0.05). There was no significant difference in daytime blood pressure control between the two administration methods (P> 0.05), but there was a significant difference (P <0.05) in the effect of nocturnal blood pressure control on antihypertensive effect at night. Nighttime medication was better than morning medication in blood pressure rhythm recovery (P <0.05). In the morning, 10 patients recovered to dipper and in nighttime medication, 19 patients returned to dipper. CONCLUSION: Both bisoprolol administrations are safe and effective in lowering blood pressure, but it is better for blood pressure rhythm recovery in non-dipper hypertensive patients at night than in morning.