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为提高卵巢癌的化疗效果 ,提高患者的生存率 ,设计了一种新型的化疗方法—持续腹腔冲洗化疗法。将 2 9例卵巢上皮癌患者随机分为持续腹腔冲洗组 (WIP组 ,14例 )和常规腹腔化疗组 (CIP组 ,15例 )。 WIP组腹腔化疗时首先注入生理盐水 2 0 0 0 m l+顺铂 (CDDP) 70 mg/m2后放开出液管 ,继以生理盐水 5 0 0 ml+CDDP17.5 mg/m2进行持续腹腔冲洗化疗 ,每 2小时 1瓶 ,进出液保持平衡 ,治疗总时间为 12小时 ,CDDP总入量为 175 m g/m2 。结果 WIP组 CR+PR率为 4 3% ,CIP组为 13% ,P<0 .0 5 ;尿 β2 M在两组的变化具有统计学意义(P<0 .0 5 )。由于加强了管理 ,WIP组毒副作用并未增加 (P>0 .0 5 ) ,患者也可耐受。认为此方法可大大改善卵巢癌患者的预后
In order to improve the chemotherapy effect of ovarian cancer and improve the survival rate of patients, a new chemotherapy method was designed-continuous peritoneal irrigation chemotherapy. Twenty-nine patients with epithelial ovarian cancer were randomly divided into continuous intraperitoneal washing group (WIP group, 14 cases) and conventional intraperitoneal chemotherapy group (CIP group, 15 cases). In the WIP group, a saline solution of 2000 mg / m2 and a cisplatin (CDDP) of 70 mg / m2 were injected into the liquid tube first, followed by continuous intraperitoneal irrigation with 500 ml of saline and CDDP 17.5 mg / m2 Chemotherapy, 1 bottle every 2 hours, balance between intake and discharge, total duration of treatment of 12 hours, total CDDP intake of 175 mg / m2. Results The CR + PR rate in WIP group was 43%, in CIP group was 13%, P <0.05; the urinary β2 M in the two groups was statistically significant (P <0.05). Toxic side effects did not increase (P> 0.05) in the WIP group due to better management and patients were tolerated. That this method can greatly improve the prognosis of ovarian cancer patients