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目的：观察根除幽门螺杆菌（ＨＰ）对预防十二指肠溃疡再出血的疗效。方法：将８０例ＨＰ感染的十二指肠溃疡并出血患者随机分为两组。治疗组应用奥美拉唑加羟氨苄青霉素进行根除ＨＰ治疗；对照组单独用奥美拉唑治疗，４周后停药追踪观察１８个月。结果：治疗组和对照组的溃疡愈合率分别为１００％、９７．１％，两组比较差异无显著性（Ｐ＞０．０５）。但ＨＰ根除率治疗组为８０．４％，对照组为１７．６％，差异有显著性（Ｐ＜０．０１）；随访１８月后，治疗组和对照组再出血率分别为２．７％和３２．１％，差异有显著性（Ｐ＜０．０１）。结论：用奥美拉唑加羟氨苄青霉素根除ＨＰ对十二指肠溃疡再出血有显著的预防作用。
Objective: To observe the efficacy of eradication of Helicobacter pylori (HP) in the prevention of rebleeding of duodenal ulcer. Methods: Eighty patients with HP-infected duodenal ulcer and bleeding were randomly divided into two groups. In the treatment group, omeprazole and amoxicillin were used to eradicate HP. The control group was treated with omeprazole alone. After 4 weeks, the drug withdrawal was observed for 18 months. Results: The healing rates of ulcer in treatment group and control group were 100% and 97.1% respectively, there was no significant difference between the two groups (P> 0.05). However, the eradication rate of HP was 80.4% in the treatment group and 17.6% in the control group, with significant difference (P <0.01). After 18 months of follow-up, the rates of hemorrhage in the treatment group and the control group were 2.7 % And 32.1%, the difference was significant (P <0.01). Conclusion: Omeprazole plus amoxicillin to eradicate HP has a significant preventive effect on the rebleeding of duodenal ulcer.