本文选用SAR-55株戊型肝炎病毒(HEV)静脉感染5只爪哇猴,收集感染前、后的血液和粪便作检查。虽然5只动物均出现丙氨酸转氨酶(ALT)和异柠檬酸脱氢酶(ICD)升高,血液及粪便中存在病毒,且抗体阳转,但却有两种不同的类型。3只动物(Cyno-375、379、381)出现相同的感染模型,感染的最初症状表现在接种后6～8天,粪便中出现HEV基因组,12～21天血清中出现病毒,病毒血症结束或在其后不久(接种后3～4周),ALT和ICD才升高,在病毒血症结束或ALT升高开始时发生血清抗体阳转。4 In this paper, 5 javanica monkeys were infected by SAR-55 HEV and the blood and faeces were collected before and after infection. Although ALT and ICD were elevated in all five animals, viruses were present in blood and feces and the antibody was positive, there were two different types. The same infection pattern occurred in 3 animals (Cyno-375, 379, 381). The initial symptoms of infection were HEV genomes in the stool 6-8 days after inoculation, viruses in the serum from 12-21 days, and viremia over Or shortly thereafter (3 to 4 weeks after vaccination), ALT and ICD are elevated and seroconversion at the beginning of viremia or ALT elevation begins. 4