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目的探讨妊娠合并乙肝病毒感染对妊娠生化指标及妊娠结局的影响。方法回顾性对比分析642例妊娠合并乙肝病毒感染(乙肝组)和642例妊娠无乙肝病毒感染(aY-常妊娠组)的常规生化指标及妊娠结局。结果 (1)乙肝组TP,ALB显著低于正常妊娠组;TB,DB,ALT,AST,GGT,TBA,GCT显著高于正常妊娠组:ALP与正常妊娠组无差别。(2)妊娠合并乙肝病毒感染和正常妊娠母体的并发症分别为:IGTl0.8%,6.2%:GDM10.3%,4.8%;PIH5.3%,1.1%;产后出血11.5%,4.0%;蛋白尿17.9%,7.5%;尿WBC阳性25.5%.7-8%;尿RBC阳性21.8,6.9%;血清总胆红素升高5.8%,0.6%;肝酶升高21.8%,2.8%。(3)妊娠合并乙肝病毒感染和正常妊娠新生儿并发症的发生率分别为:早产9.7%,2.7%;黄疸32.1%,8.3%;肺炎5.6%,1.9%:小样儿3.6%,l.2%;窒息4.1%,l.2%。结论妊娠合并乙肝病毒感染妊娠母体和新生儿各类并发症的发生率明显高于正常妊娠孕妇,临床应加强对妊娠合并乙肝病毒感染的母婴监测,减少并发症的发生,提高母婴健康。
Objective To investigate the impact of pregnancy with hepatitis B virus infection on biochemical markers of pregnancy and pregnancy outcome. Methods A retrospective analysis of 642 cases of pregnancy with hepatitis B virus infection (hepatitis B) and 642 cases of pregnancy without hepatitis B virus infection (aY-normal pregnancy group) conventional biochemical indicators and pregnancy outcomes. Results (1) The levels of TP and ALB in hepatitis B group were significantly lower than those in normal pregnancy group. The levels of TB, DB, ALT, AST, GGT, TBA and GCT in HBV group were significantly higher than those in normal pregnancy group. There was no difference between ALP group and normal pregnancy group. (2) The complications of pregnancy with hepatitis B virus infection and normal pregnancy were as follows: IGT10.8%, 6.2%: GDM10.3%, 4.8%; PIH5.3%, 1.1%; postpartum hemorrhage 11.5%, 4.0% Proteinuria 17.9%, 7.5%; urine WBC positive 25.5% .7-8%; urine RBC positive 21.8,6.9%; serum total bilirubin increased 5.8%, 0.6%; liver enzymes increased 21.8%, 2.8%. (3) The incidence of neonatal complications of pregnancy complicated with hepatitis B virus infection and normal pregnancy were as follows: premature delivery 9.7%, 2.7%; jaundice 32.1%, 8.3%; pneumonia 5.6%, 1.9%: small sample 3.6% %; Choking 4.1%, l.2%. Conclusions The incidence of complications of pregnancy complicated by hepatitis B virus infection in pregnant women and newborns was significantly higher than that of normal pregnant women. The monitoring of mother-infant pregnancy with hepatitis B virus infection should be strengthened to reduce the incidence of complications and improve the health of mother and baby.