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内皮素(endothelin,ET)系广泛分布于中枢神经系统及外周各类组织的活性多肽,是心血管活动的重要调节因子之一,在心血管生理与病理过程中发挥重要作用[1-2]。成熟的ET是由21个或31个氨基酸残基组成[3-4],分别包括ET-1、ET-2和ET-33个成员,主要分布于心血管系统,具有收缩平滑肌、
Endothelin (ET) is an active peptide widely distributed in the central nervous system and peripheral tissues. It is one of the important regulators of cardiovascular activity and plays an important role in cardiovascular physiology and pathology [1-2]. Mature ET is composed of 21 or 31 amino acid residues [3-4], including ET-1, ET-2 and ET-33 members, respectively, mainly distributed in the cardiovascular system, with smooth muscle contraction,