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目的：探讨不同胆囊切除术手术时机对合并基础疾病的老年急性胆囊炎患者临床效果的影响。方法：将89例合并基础疾病老年急性胆囊炎患者根据不同手术时间分为早期组（n=42，发病72h内手术）和晚期组（n=47，发病72h后手术），均行腹腔镜胆囊切除术，比较两组患者的手术情况及术后恢复情况。结果：早期组组织粘连程度分布（30.95%、59.53%、7.14%、2.38%）显著优于晚期组（Z=2.062，P＜0.05）；早期组住院时间（5.51±2.13）d、住院费用（8271.9±1044.2）元均明显低于晚期组（t=-6.675、-6.866，P＜0.05）；两组患者手术时间、术中出血量、并发症发生率比较差异无统计学意义（P＞0.05）。结论：对合并基础疾病的老年急性胆囊炎患者早期发病72h内行胆囊切除术手术有利于促进患者康复，减少了住院费用，值得临床重视。“,”Objective To investigate the opportunity of cholecystectomy for elderly patients with acute cholecystitis complicated with basic diseases.Methods 89 cases with basic diseases in elderly patients with acute cholecystitis divided according to different operation time for the early group (n=42, operation within 72 hours after onset) and late group (n=47, 72 hours after onset of symptom after surgery) underwent laparoscopic gallbladder resection, the surgery and postoperative recovery condition were compared between the two groups.Results Early tissue adhesion degree distribution (30.95%, 59.53%, 7.14%, 2.38%) was significantly better than the late group (Z=2.062,P<0.05);early group, the hospitalization time (2.13±5.51)d, hospitalization expenses (8271.9±1044.2) yuan were significantly lower than the late group (t=-6.675,-6.866,P0.05).Conclusion The early onset of 72h in the elderly patients with acute cholecystitis with basic disease of the disease can promote the rehabilitation of patients and reduce the hospitalization expenses,it is worthy of clinical attention.