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一、用N-甲基-N′-硝基-N-亚硝基胍(MNNG)100μg/ml诱发大鼠腺胃腺癌的发生率为35.7％(5/14);而空白对照组未见任何明显的病变及肿瘤发生。二、用MNNG100μg/ml处理大鼠的同时,连续15个月喂给中药大枣的Ⅲ组腺胃腺癌的发生率为15.4％(2/13),胃肠道恶性肿瘤总的发生率为38.4％(5/13);用MNNG100μg/ml处理大鼠7个月后,连续8个月投给大枣的Ⅳ组腺胃腺癌的发生率为21.7％(5/23),胃肠道癌瘤总的发生率为34.8％(8/23),与Ⅱ组(MNNG)胃肠道癌瘤的发生率71.14％(10/14)相比,经
The incidence of glandular gastric adenocarcinoma in rats induced by N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) 100μg/ml was 35.7% (5/14); however, no control group was found. Any obvious lesions and tumors occur. 2. At the same time when rats were treated with MNNG 100 μg/ml, the incidence of glandular gastric adenocarcinoma of group III fed with jujube for 15 consecutive months was 15.4% (2/13), and the overall incidence of gastrointestinal malignancy was 38.4. % (5/13); After 7 months of treatment with MNNG 100 μg/ml, the incidence of glandular gastric adenocarcinoma in IV group was 21.7% (5/23) for 8 consecutive months. The overall incidence was 34.8% (8/23), compared with 71.14% (10/14) of the gastrointestinal cancers in Group II (MNNG).