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目的为青蒿琥酯现场推广应用提供优化方案。方法选择安徽省铜陵市灰河乡太阳村江滩型血吸虫病重流行区 ,采用随机方法将人群分为 A、B两组 ,A组在整个感染季节实施全民口服青蒿琥酯预防药物 ;B组则根据试区不同人群接触疫水特点而给予不同预防服药方案。各实验组分别设相应的安慰剂对照组。统计实施 A、B两方案的各项成本费用并进行各方案的费用效果分析。结果实施 A、B两方案后人群感染率分别为0和 0 .1 4 % ,而安慰剂对照组的感染率分别为 5.2 5%和 6.61 %。实施 A方案的人均成本费用为 4 5.4 4元 ,B方案为 2 4 .65元。结论根据人群接触疫水特点而有针对性地给予不同的给药方案 ,其成本费用明显低于全民口服预防药物 ,而且同样可以达到预防血吸虫感染的效果。
The purpose of artesunate site promotion and application of optimization programs. Methods The schistosomiasis endemic area of Taiyang Village, Taihe Village, Tonghe City, Tongling City, Anhui Province was selected and randomly divided into groups A and B. Groups A and B received artesunate prophylaxis over the entire infectious season. B Group is based on different characteristics of the pilot exposure to different groups of patients given different preventive medication program. The experimental groups were set up the corresponding placebo control group. Statistics of the implementation of A, B program costs and costs of each program analysis. Results The prevalence rates of A and B after treatment were 0 and 0.14% respectively, while those in the placebo control group were 5.2% and 6.61%, respectively. Per capita cost of implementing Plan A was 4 5.44 yuan and Plan B was 24.55 yuan. Conclusion According to the characteristics of population exposure to contaminated water, different dosage regimens can be given in a targeted manner. The cost is obviously lower than that of oral preventive drugs, and the effect of preventing schistosomiasis infection can also be achieved.