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目的探讨抗痫制剂对戊四氮致痫小鼠学习、记忆力改变的影响。方法健康成年雄性小鼠60只,随机分为空白对照组,模型对照组,抗痫制剂大剂量组、中剂量组、小剂量组和丙戊酸钠组,每组10只。抗痫制剂大、中、小剂量组小鼠分别以抗痫制剂14.8 mg/g、7.4 mg/g和3.7 mg/g灌胃,每天1次,连续7 d;复制戊四氮诱导急性癫痫模型;水迷宫测定抗痫制剂对致痫小鼠学习和记忆力的影响。结果与空白对照组相比,模型对照组小鼠逃避潜伏期延长,行程出错率增加(P<0.05);与模型对照组和丙戊酸钠组相比,抗痫制剂大、中、小剂量组小鼠逃避潜伏期缩短、行程出错率减少(P<0.05)。与模型对照组相比,丙戊酸钠组小鼠逃避潜伏期、行程出错率均值虽增加,但差异无统计学意义(P>0.05)。结论模型对照组和丙戊酸钠组小鼠学习、记忆力降低;抗痫制剂能缩短模型小鼠水迷宫逃避潜伏期,减少行程出错率,明显改善致痫小鼠学习记忆能力。
Objective To investigate the effects of antiepileptic agents on learning and memory in mice with epilepsy induced by pentylenetetrazole. Methods Sixty healthy adult male mice were randomly divided into blank control group, model control group, anti-epileptic preparations of high-dose group, middle-dose group, low-dose group and sodium valproate group, with 10 in each group. The anti-epileptic preparations of large, medium and small doses of mice were intragastrically administered anti-epileptic preparations of 14.8 mg / g, 7.4 mg / g and 3.7 mg / g, once a day for 7 days; Pentylenetetrazol-induced acute epilepsy model ; Water maze Determination of anti-epileptic agents on learning and memory of epileptic mice. Results Compared with the blank control group, the model control mice prolonged the escape latency and increased the stroke error rate (P <0.05). Compared with the model control group and the sodium valproate group, the anti-epileptic agents in the large, medium and low dose groups Mice escape latency shortened stroke error rate decreased (P <0.05). Compared with the model control group, the average escape error and the error rate of stroke in the sodium valproate group increased, but the difference was not statistically significant (P> 0.05). Conclusion The model control group and sodium valproate group mice learning and memory reduced; anti-epileptic preparations can shorten the water maze escape latency of mice, reduce stroke error rate, significantly improve the learning and memory ability of mice with epilepsy.