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目的:了解广州市学龄前儿童乙肝疫苗的免疫效果,为乙肝疫苗加强免疫提供科学依据。方法:采用化学发光微粒子免疫分析法(CMIA)定量检测2 542名广州市0～6岁HBsAg阴性儿童血清抗-HBs浓度。结果:CMIA检测广州市0～6岁儿童血清抗-HBs总体阳性率为94.34%,随着年龄增长,血清抗-HBs阳性率逐渐降低,组间差异存在统计学意义(P<0.01);血清抗-HBs浓度亦逐渐下降,组间差异有统计学意义(P<0.01)。结论:广州市学龄前儿童乙肝免疫整体处于较高水平,但由于抗体的时效性,应定期检测血清抗-HBs浓度,及时复种加强免疫。
Objective: To understand the immune effect of hepatitis B vaccine among preschool children in Guangzhou and to provide a scientific basis for enhancing the immunity of hepatitis B vaccine. Methods: Chemiluminescent microparticle immunoassay (CMIA) was used to quantitatively detect serum anti-HBs concentrations in 2 542 HBsAg negative children aged 0-6 years in Guangzhou. Results: The overall positive rate of serum anti-HBs in Guangzhou children aged 0-6 years was 94.34%. With the increase of age, the positive rate of anti-HBs in serum decreased gradually with statistical significance (P <0.01). Serum The anti-HBs concentration also gradually decreased, with significant difference between the two groups (P <0.01). Conclusion: The overall level of hepatitis B immunization in preschool children in Guangzhou is relatively high. However, due to the timeliness of the antibody, serum anti-HBs levels should be regularly tested and the immunizations should be promptly repeated.