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探讨了给予二甲基亚硝胺（ＮＤＭＮ），同时补充β－胡萝卜素（β－Ｃ）后，大鼠体内抗氧化酶活性和脂质过氧化物含量的变化。结果显示，一定剂量的ＮＤＭＮ可使大鼠血红细胞、肝肾匀浆ＳＯＤ活性和全血ＧＳＨ－Ｐｘ活性下降（Ｐ＜０．０５），血清和肝ＭＤＡ和血清ＲＯＯＨ产生增多（Ｐ＜０．０５）。添加β－Ｃ（２５ｍｇ／ｋｇ）后，ＳＯＤ和ＧＳＨ－Ｐｘ活性均比单纯ＮＤＭＮ组有明显提高（Ｐ＜０．０５）。ＭＤＡ和ＲＯＯＨ含量明显低于ＮＤＭＮ组（Ｐ＜０．０５）。提示自由基和脂质过氧化反应可能也是ＮＤＭＮ及其它亚硝胺致癌的途径之一；一定剂量的β－Ｃ可对抗ＮＤＭＮ引起的自由基和脂质过氧化。
The changes of antioxidant enzyme activity and lipid peroxide content in rats after administration of dimethylnitrosamine (NDMN) supplemented with β-carotene (β-C) were investigated. The results showed that a certain dose of NDMN could decrease SOD activity and whole blood GSH-Px activity in rat red blood cells, liver and kidney homogenate (P<0.05), increase serum and liver MDA and serum ROOH (P<0. 05). After adding β-C (25 mg/kg), the activities of SOD and GSH-Px were significantly higher than those of NDMN alone (P<0.05). The content of MDA and ROOH was significantly lower than that of NDMN group (P<0.05). It is suggested that free radicals and lipid peroxidation may be one of the pathways of carcinogenesis induced by NDMN and other nitrosamines; a certain dose of β-C can counteract free radical and lipid peroxidation caused by NDMN.