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目的探讨并比较维吾尔族与汉族支气管哮喘患儿血清白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)及Ig E水平的变化及临床意义。方法采用双抗夹心酶联免疫法(ELISA)分别测定100例汉族及100例维族哮喘患儿急性发作期、缓解期血清中IL-6、TNF-α及Ig E水平,并以200例健康儿童为对照。结果维族与汉族哮喘急性发作期患儿血清中IL-6、TNF-α及Ig E水平均高于哮喘缓解期及对照组,缓解期3项指标仍高于对照组,差异有统计学意义(P<0.05)。维族对照组及哮喘缓解期、急性发作期IL-6水平均高于汉族,哮喘急性发作期与缓解期TNF-α低于汉族,急性发作期Ig E水平高于汉族,差异均有统计学意义(P<0.05)。结论维族及汉族支气管哮喘患儿不同时期血清中IL-6、TNF-α及Ig E水平存在差异,掌握其变化规律对指导两民族支气管哮喘患儿的诊断及治疗具有十分重要的临床价值。
Objective To investigate and compare the changes of serum interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α) and IgE in Uygur and Han children with bronchial asthma and its clinical significance. Methods Serum levels of IL-6, TNF-α and Ig E in 100 Han and 100 Uighur asthma children were detected by ELISA. The serum levels of IL-6, TNF-α and Ig E in 200 healthy children As a control. Results The levels of IL-6, TNF-α and IgE in sera of children with Uygur and Han nationality acute exacerbation were higher than those of asthma remission and control group. The remission indicators of the three indicators were still higher than those of the control group (the difference was statistically significant ( P <0.05). IL-6 levels in Uygur control group, asthma exacerbation and acute exacerbation were all higher than those in Han nationality, the level of TNF-α in acute asthma exacerbation and remission was lower than that in Han nationality, and the level of IgE in acute exacerbation was higher than that in Han nationality (P <0.05). Conclusions The levels of IL-6, TNF-α and IgE in serum of Uygur and Han children with bronchial asthma differ at different stages. It is of great clinical value to study the changes of serum IL-6, TNF-α and IgE levels in the diagnosis and treatment of children with bronchial asthma.