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严重慢性阻塞性肺疾病(COPD)患者可由于代谢性酸中毒刺激颈动脉体的化学感受器使运动通气需求量增加,并由于通气受限而限制运动。 本研究旨在确定运动时提高碳酸氢盐水平是否可降低酸对呼吸化学感受器的刺激,从而改善COPD患者的运动耐力;同时也与服用碳酸氢钠后再吸入100％氧气(已知吸氧可降低COPD患者每分钟通气量)及健康年轻人的运动反应进行比较。6名没有慢性二氧化碳潴留的严重COPD患者(第1
In patients with severe chronic obstructive pulmonary disease (COPD), carotid body chemosensors may be stimulated by metabolic acidosis to increase the demand for exercise ventilation and to limit movement due to restricted ventilation. The aim of this study was to determine whether increasing bicarbonate during exercise reduces the acid stimulation of the chemoreceptors to improve exercise tolerance in patients with COPD and also inhales 100% oxygen after taking sodium bicarbonate Reduce COPD patients minute ventilation) and healthy young people’s motor response were compared. Six patients with severe COPD without chronic carbon dioxide retention (section 1