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目的探讨多囊卵巢综合征(PCOS)患者血清性激素水平、皮质醇(Cor)变化及临床意义。方法 50例PCOS患者(PCOS组)和47例正常妇女(对照组)在早晨空腹采血,采用电化学发光法和放射免疫分析法测定血清硫酸脱氢表雄酮(DHEA)、性激素结合球蛋白(SHBG)、17羟孕酮(17-OHP)、雌二醇(E2)、睾酮(T)、泌乳素(PRL)、黄体生成素(LH)、促卵泡刺激素(FSH)及Cor等指标。结果 PCOS组患者血清DHEA、17-OHP、T和LH均明显高于对照组(P<0.01),而SHBG、PRL和Cor低于对照组(P<0.01)。结论联合检测血清DHEA、17-OHP、SHBG、T、PRL、LH和Cor有助于PCOS患者的诊断和治疗。
Objective To investigate the changes of serum sex hormone levels and cortisol (Cor) in patients with polycystic ovary syndrome (PCOS) and its clinical significance. Methods Fifty PCOS patients (PCOS group) and 47 normal women (control group) were taken fasting blood in the morning, and the levels of serum DHEA and sex hormone binding globulin were determined by electrochemiluminescence and radioimmunoassay. (SHBG), 17-OHP, E2, T, PRL, LH, FSH and Cor were measured. Results The serum levels of DHEA, 17-OHP, T and LH in PCOS group were significantly higher than those in control group (P <0.01), while SHBG, PRL and Cor were lower than those in control group (P <0.01). Conclusions Combined detection of serum DHEA, 17-OHP, SHBG, T, PRL, LH and Cor can be helpful for the diagnosis and treatment of PCOS.