在ＩＣＵ内的重危病人中，选取了两组呼吸衰竭，给予呼吸机支持的病人进行随机对比分析：Ａ组（ｎ＝２０）进行ＰＮ治疗，Ｂ组（ｎ＝２０）未进行ＰＮ治疗。通过对通气／换气功能各指标的分析，发现两组病人在呼吸频率，ｐＨ，ＰａＯ２，ＨＣＯ－３指标上无明显差异。但ＰＮ组ＰａＯ２／ＦｉＯ２轻度降低而Ａ－ａＤＯ２及肺内分流明显升高。本文提示ＰＮ中的脂肪乳剂和高糖可能是导致呼吸功能改变的重要因素。 Among the critically ill patients in the ICU, two groups of patients with respiratory failure were selected and randomly assigned to receive ventilator support: group A (n = 20) received PN and group B (n = 20) received no PN. Through the analysis of each index of ventilation / ventilation function, it was found that there was no significant difference in respiratory rate, pH, PaO2 and HCO-3 between the two groups. However, PaO2 / FiO2 in PN group decreased slightly while A-aDO2 and pulmonary shunt were significantly increased. This article suggests that fat emulsions and high sugars in PN may be important factors that lead to altered respiratory function.