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目的探讨由护理人员主导的综合干预对乙肝病毒相关性肝癌TACE患者药物依从性的影响。方法本研究采用随机抽样的方法纳入96例某三级甲等肿瘤医院介入科曾接受TACE治疗并服用核苷酸类似药物1个月的乙肝病毒相关性肝癌患者。患者在知情同意的前提下,接受由护理人员主导的、医师和护士共同实施的综合干预。结果 (1)干预后的服药依从性得分平均值(93.67±6.046)高于干预前(82.04±10.024)(P<0.05),干预后服药依从性良好的患者的比率(97.8%)高于干预前(62.4%)(P<0.05);(2)干预后血清HBVDNA处于正常范围的患者比率(45.16%)高于干预前(15.05%)(P<0.05)。结论由护理人员主导的综合干预能有效改善乙肝病毒相关性肝癌TACE患者药物依从性,有利于控制血清HBVDNA水平。
Objective To explore the influence of comprehensive intervention led by nurses on drug compliance of TACE patients with hepatocellular carcinoma associated with hepatitis B virus. Methods In this study, a random sample of 96 patients with Tier III tumors in a hospital of Grade III Tumor Hospital who had been treated with TACE and taking nucleotide analogous drugs for 1 month were enrolled in this study. Under informed consent, patients receive a combination of interventions led by caregivers and implemented by physicians and nurses. Results (1) The mean score of medication adherence after intervention (93.67 ± 6.046) was higher than that before intervention (82.04 ± 10.024) (P <0.05), and the rate of medication compliance was higher after intervention (97.8%) than intervention (62.4%) (P <0.05). (2) The percentage of patients with normal serum HBVDNA after intervention (45.16%) was higher than that before intervention (15.05%) (P <0.05). Conclusion The comprehensive intervention led by nursing staff can effectively improve the drug compliance of TACE patients with hepatocellular carcinoma associated with hepatitis B virus, which is beneficial to control the serum HBV DNA level.