CD4+CD25+调节性T细胞(Treg)是体内具有免疫调节功能的一类特殊T细胞亚群。近年来,国内外的大量研究表明Treg与很多种心血管疾病的发生和进展密切相关。因此,认识Treg及其在心脏疾病中免疫抑制的机制,有助于提高心脏疾病的免疫治疗效果。现就CD4+CD25+Treg的产生、特征、作用机制及其与心脏疾病的联系予以综述。 CD4 + CD25 + regulatory T cells (Tregs) are a group of specialized T cell subsets that have immunomodulatory functions in vivo. In recent years, a large number of studies both at home and abroad show that Treg is closely related to the occurrence and progression of many cardiovascular diseases. Therefore, the understanding of Treg and its mechanism of immunosuppression in heart disease can help to improve the immunotherapy effect of heart disease. Now on the CD4 CD25 Treg generation, characteristics, mechanism of action and its relationship with heart disease are reviewed.