【摘 要】
：
A mathematical model describing the antiretroviral therapy of Enfuvirtide on HIV-1 patients is developed. The effect of Enfuvirtide (formerly called T-20) by im
【机 构】
：
Department of Mathematical Sciences,Department of Mathematics,Scientific Research Department
【基金项目】
：
Project supported by the National Natural Science Foundation of China;the Shanghai Leading Academic Discipline Project;the International Development Research Center of Canada;the Ministry of Health of
论文部分内容阅读
A mathematical model describing the antiretroviral therapy of Enfuvirtide on HIV-1 patients is developed. The effect of Enfuvirtide (formerly called T-20) by impulsive differential equations is modeled by two different drug elimination kinetics, the first-order elimination kinetics and the Michaelis-Menten elimination kinetics. The model is a non-autonomous system of differential equations. For a time-dependent system, the disease-free equilibrium is mainly studied. Its stability, when the therapy is taken with perfect adherence, is obtained. To ensure the disease-free equilibrium remains stable, the analytical thresholds for dosage and dosing intervals are determined. The effects of supervised treatment interruption are also explored. It is shown that the supervised treatment interruption can be worse than no therapy at all.
其他文献
A series of carbonaceous mesophase spherule/activated carbon composites were prepared as anode materials for super lithium ion capacitors using carbonaceous mes
The mechanical characters of CdZnTe crystal were investigated by nanoscratch tests,and the effects of mechanical anisotropy on the material removal rate and sur
The preparation of granulated adsorption material of water-quenched slag/rectorite composite and the treatment of Cu (Ⅱ)-containing copper smelter wastewater w
The distribution of shear stress on the cross-section of plastic metal solid circular shaft under pure torsion yielding,the applicability of complete plastic mo
Formation and evolution of secondary streamwise vortices in the compressible transitional boundary layers over a flat plate are studied using a direct numerical
In some object tracking systems,the moving object future position is an area (i.e.,target area).It is a successful estimation strategy if the predicted points f
The asymptotic behavior of solutions of a similarity equation for the laminar flow in a porous channel with suction at both expanding and contracting walls has
Aiming at developing novel microwave-transparent ceramics with low dielectric loss,high thermal conductivity and high strength,Si3N4-AlN (30％,mass fraction) comp
Perturbation and robust controllability of the singular distributed parameter control system am discussed via functional analysis and the theory of GE-semigroup
The high-temperature mechanical properties and microstructure of forging billets of C-Si-Mn-Cr and C-Si-Mn-Cr-Mo ultra-high-strength cold-rolled steels (tensile