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目的探讨血清半胱氨酸蛋白酶抑制剂C(Cystatin C,Cys C)、尿微量白蛋白(mAlb)和视黄醇结合蛋白(retinol binding protein,RBP)联合检测对诊断早期糖尿病肾病的价值。方法在日立7600-020全自动生化分析仪上,分别检测198例糖尿病患者及42例健康对照组血清Cys C、尿mAlb、RBP和尿肌酐(UCr)的含量。结果糖尿病患者血清CysC、尿mAlb、RBP均明显高于正常对照组,差异有统计学意义(P<0.01)。结论血清CysC、尿mAlb、RBP均可做为糖尿病早期肾损害的灵敏指标,三者联合检测的诊断意义更大。
Objective To investigate the diagnostic value of serum Cystatin C (Cys C), microalbuminuria (mAlb) and retinol binding protein (RBP) in the diagnosis of early diabetic nephropathy. Methods Serum Cys C, urinary mAlb, RBP and urinary creatinine (UCr) were detected in 198 patients with diabetes mellitus and 42 healthy controls on Hitachi 7600-020 automatic biochemical analyzer. Results The serum CysC, urine mAlb and RBP in diabetic patients were significantly higher than those in normal controls (P <0.01). Conclusions Serum CysC, urine mAlb and RBP can be used as sensitive indicators of early diabetic nephropathy. The diagnostic value of combined detection of the three is more significant.