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目的 :评价植入式芯片系统调控血压的效果。方法 :麻醉状态下记录家兔平均动脉压 (ＭＡＰ)和心率(ＨＲ)。根据调定点学说 ,设计了一种植入式芯片系统 ,根据血压的反馈信息 ,经过芯片运算处理 ,即时改变刺激主动脉神经 (ＡＤＮ)的脉冲频率 ,从而调控血压。每只家兔分别给予两次芯片系统控制的血压调控 ,持续时间分别为 1 5ｍｉｎ和 60ｍｉｎ。结果 :与对照相比 ,第一次调控和第二次调控分别使平均动脉压 (ＭＡＰ)降低 (3 2 .0± 6.6)ｍｍＨｇ和 (2 7.4± 6.2 )ｍｍＨｇ ,差异均有显著性 ,而调控前 (对照 )与调控结束后 (恢复期 )的ＭＡＰ水平差异无显著性。与对照相比 ,两次调控均引起ＨＲ显著降低。调控结束后ＭＡＰ和ＨＲ均迅速恢复至正常水平 ,未产生反跳。结论 :植入式芯片系统能有效地将血压控制在设定范围 ,且未产生适应现象。
Objective: To evaluate the effect of implantable chip system on blood pressure control. Methods: Rabbits were anesthetized under the mean arterial pressure (MAP) and heart rate (HR). According to the set point theory, an implanted chip system is designed, which adjusts the blood pressure according to the feedback information of blood pressure through the chip operation processing, and instantly changes the pulse frequency of stimulating aortic nerve (ADN). Each rabbit was given twice a chip system-controlled blood pressure control, duration of respectively 15min and 60min. RESULTS: Compared with the control, the first and second regressions decreased mean arterial pressure (MAP) by (3.2 ± 6.6) mmHg and (± 7.4 ± 6.2) mmHg, respectively, with significant differences There was no significant difference in MAP levels between pre-control (control) and control (recovery). Both regimens caused a significant decrease in HR compared to controls. After the regulation and control, MAP and HR both returned to normal level quickly, and no rebound occurred. Conclusion: Implantable chip system can effectively control the blood pressure within the set range, and did not produce adaptation.