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本工作比较了氯仿(CF)和氯苯(CB)对家兔肺泡巨噬细胞(AM)的离体毒性。将AM与不同浓度毒物在37℃混合,数分钟后测得CB染毒AM的存活率从15mM开始急速下降,25mM左右几乎100％死亡。而直到30mμ的cF并不引起AM死亡率明显增加。CB对AM吞噬能力的抑制也比CF大。CB的较大毒性可能与其对细胞膜的破坏力较强有关,溶血试验结果证实了这一点,CB引起RBC
This work compared the in vitro toxicity of chloroform (CF) and chlorobenzene (CB) to rabbit alveolar macrophages (AM). AM and different concentrations of poisons were mixed at 37 ° C. After several minutes, the viability of AM infected with CB dropped rapidly from 15mM and almost 100% died at 25mM. Up to 30 mμ cF did not cause a significant increase in AM mortality. CB inhibition of AM phagocytosis than CF. The greater toxicity of CB may be related to its strong destructive effect on the cell membrane, which is confirmed by the results of hemolysis test. CB causes RBC