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目的 :研究氢化小檗碱的镇痛和抗炎作用。方法 :用热板法和扭体法观察该药的镇痛作用 ;用二甲苯使小鼠致炎观察该药的抗炎作用。结果 :氢化小檗碱不同剂量灌胃给药对小鼠热致痛和醋酸致痛具有明显的镇痛作用 ,并呈现一定的量效关系 ;对二甲苯所致炎性水肿也有显著的抑制作用。结论 :氢化小檗碱具有较好的镇痛抗炎作用
Objective: To study the analgesic and anti-inflammatory effects of berberine. Methods: The analgesic effect of the drug was observed by hot plate method and writhing method. The anti-inflammatory effect of the drug was observed by using xylene to inflame the mice. RESULTS: Different doses of berberine hydrochloride administered by intragastric administration had obvious analgesic effects on thermal and acetic acid-induced pain in mice, and showed a certain dose-effect relationship. It also had significant inhibitory effect on inflammatory edema induced by xylene. . Conclusion : Hydrogenated berberine has better analgesic and anti-inflammatory effects