论文部分内容阅读
目的 探讨先天性巨细胞病毒感染的临床特点及检测手段。方法 对 15例经尿CMV DNA/PCR及血清CMV IgM抗体测定确诊为先天性巨细胞病毒感染的新生儿患者的临床资料进行总结分析。结果 15例新生儿日龄均 <14d ,尿CMV DNA/PCR阳性 11例 ,血CMV IgM阳性 9例 ,两者同时阳性 5例。临床表现为黄疸 12例 ,肝肿大 5例 ,脾肿大 2例 ,小头 2例 ,皮肤出血点 3例 ,小眼球 2例 ,咳嗽、气促 4例 ,合并先天性心脏病 1例 ,贫血 2例 ,支气管肺炎 4例。结论 用PCR检测尿液中CMV DNA和用ELISA检测血清中抗CMV IgM抗体是诊断CMV感染的常用方法 ,但以前者的敏感度高。新生儿先天性巨细胞病毒感染以肝脏损害多见 ,还可累及中枢神经系统和肺等脏器 ,是我国小儿致畸致残的主要原因之一。
Objective To investigate the clinical characteristics and detection of congenital cytomegalovirus infection. Methods The clinical data of 15 neonates diagnosed as congenital cytomegalovirus infection by CMV DNA / PCR and serum CMV IgM antibody were analyzed. Results All 15 newborns were less than 14 days old, 11 were positive for CMV DNA / PCR and 9 were CMV IgM positive, both of which were positive in 5 cases at the same time. The clinical manifestations were jaundice in 12 cases, hepatomegaly in 5 cases, splenomegaly in 2 cases, small head in 2 cases, skin bleeding in 3 cases, small eyeball in 2 cases, cough, shortness of breath in 4 cases, congenital heart disease in 1 case, 2 cases of anemia, 4 cases of bronchial pneumonia. Conclusions PCR detection of CMV DNA in urine and detection of serum anti-CMV IgM antibodies by ELISA are common methods for the diagnosis of CMV infection, but the former are highly sensitive. Neonatal congenital cytomegalovirus infection more common in liver damage, but also involving the central nervous system and lungs and other organs, is one of the main causes of teratogenic and pediatric children in China.