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目的探讨颈肩痛的发病机制。方法用免疫组化ABC法观察人颈段脊柱结构内神经元型一氧化氮合酶(nNOS)免疫反应阳性神经末梢情况。结果人颈椎关节突关节囊的纤维层、黄韧带、棘间韧带、棘上韧带和椎间盘的纤维环内均有nNOS免疫反应阳性神经末梢的存在,这些神经末梢呈树枝状或念珠状,其走行与结缔组织层平行。结论一氧化氮(NO)参与人颈椎关节突关节囊、黄韧带、棘间韧带、棘上韧带和椎间盘的纤维环等结构的伤害性感觉信息的传递。人颈段脊柱相关结构的神经末梢受刺激时,促使NO的释放和传递可能是引起原发性颈肩痛的原因之一。
Objective To explore the pathogenesis of neck and shoulder pain. Methods Immunohistochemical ABC method was used to observe the expression of neuronal nitric oxide synthase (nNOS) immunoreactive nerve endings in human cervical spine. Results There were nNOS immunoreactive positive nerve endings in the fibrous layer of the cervical capsular joint capsule, the ligamentum flavum, the interspinous ligament, the supraspinous ligament and the intervertebral disc. These nerve endings were dendritic or rosary. Parallel to the connective tissue layer. Conclusion Nitric oxide (NO) participates in the transmission of nociceptive information of the structures of the cervical spondylotic joint capsule, the ligamentum flavum, the interspinous ligament, the supraspinous ligament and the intervertebral disc. When the nerve endings of the cervical spine related structures are stimulated, the release of NO and its transmission may be one of the causes of primary neck and shoulder pain.